Police are appealing for witnesses after a 75-year-old Craiglie woman was seriously assaulted in Port Douglas Last night

Police were called to Nautilus Street at 8.30pm on Friday after a woman was located injured in the street.

At approximately 6.30pm, the woman was walking along Nautilus Street towards Mitre Street when she was assaulted by two people.

The force of the assault caused the woman to fall to the ground, knocking her unconscious.

It is believed the woman was left unconscious by the road for approximately two hours before passers-by found her and contacted police.

She received serious head injuries and was transported to the Mossman hospital in a serious condition. The woman remains in hospital in a stable condition.

Police are appealing for any witnesses who were in the area between 6.30pm and 8.30pm, or any motorist who may have dashcam vision to contact police.

If you have any information, contact Policelink on 131 444 or provide information using the online form 24hrs per day.

You can report information about crime anonymously to Crime Stoppers, a registered charity and community volunteer organisation, by calling 1800 333 000 or via crimestoppersqld.com.au 24hrs per day.