UPDATE SAT 8:13 PM Police are advising that waterways in the Mossman area are experiencing significant rises due to heavy rainfall.  

As a result they are expecting flooding and considerable surface water on local roads and streets.

Residents are advised to remain indoors and to undertake travel only if absolutely necessary, and to consult the traffic and travel information website for current road information. 

Sergeant Damian Meadows said leaving your home isn't worth the risk.

"I strongly urge people to stay indoors unless there is an absolute necessity," he said.

"There are people rubber necking and this really impacts on emergency services.

"If there's no need to be out there, don't be out there.

"This is still a long way from being over."

More than 1200 homes are without power with Mossman, Miallo and Cooya Beach experiencing significant outages. 

A tree has brought down power lines on Macrossan Street in Port Douglas causing further disruptions to power in the region. 

Emergency services are preparing for the largest flooding event at Daintree River in more than 20 years. 

'Extreme' Daintree floods

Major flood levels have peaked at Daintree River above the March 1996 flood peak of 14.62 metres, and are rising downstream at Daintree Village.

Flood levels at the village were initially expected to peak somewhere near the 11.81 metres but forecasters now predict they'll reach around 10.5 metres.

"We're talking about flood levels that could break records," Sergeant Meadows said. 

"There's a lot of weather left in this system and it's going to impact across the region." 

Rainfall totals of up to 400 millimetres were recorded across the catchment in the 24 hours to 9 am on Saturday.

Further areas of heavy rainfall of between 50mm to 100m are forecast in the Daintree River catchment for the next 24 hours.

The Daintree village is isolated and the ferry is not operating. North of the river, roads are cut in multiple locations.

Tresize Road is cut off at Springs Creek causeway.

Residents in low-lying areas are advised to monitor flood reports from the Bureau of Meteorology and prepare their homes accordingly.

Swift rescue

Queensland Ambulance Service have rushed to the aid of a seriously ill woman stranded at her Mossman home with only two hours of oxygen left.  

A swift water rescue team rushed to her aid this morning. Authorities said the woman has been treated and is in a stable condition. 

For flood emergency assistance contact the SES on 132 500.

For life threatening emergencies, call Triple Zero (000) immediately.